DEVELOPMENT AND IN-VITRO EVALUATION OF PHYTOSOMES CONTAINING HERBAL EXTRACT OF CENTELLA ASIATICA FOR ANTIULCER AND ANTIOXIDANT ACTIVITY

Herbal medications have a diverse range of active constituents allowing us to use them in variety ways, but are poorly absorbed due their strong polarity and low lipophilicity, resulting bioavailability. The aim this research was improve bioavailability by development in-vitro evaluation phytosomes containing herbal extract Centella asiatica for its antioxidant gastroprotective activity. Phytosomes were prepared reflex method further it is characterized evaluated. complex formation estimated FTIR analysis drug content entrapment efficiency achieved be 91.6% 84.3% respectively. mean diameter found 854.2 nm zeta potential 28.4 mV found. It indicates that the release higher comparison formulation i.e., 100% 77.6%. kinetics optimized phytosomal (F3) best fitted R2 value 0.9879. anti-oxidant activity superior than hydroalcoholic % inhibition 83.55 having IC50 1.99 85.31 2.77. In anti-ulcer neutralize acid more significant as compare standard asiatica. results indicated phytosome could promising candidate effective delivery constituents.